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Year : 1997  |  Volume : 29  |  Issue : 3  |  Page : 198-200

Effect of Ginkgo biloba on chemoshock in mice

Correspondence Address:
Manocha Anshu

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Source of Support: None, Conflict of Interest: None

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Objective: The present study was designed to evaluate the effect of Ginkgo biloba (a PAF antagonist) on chemoshock in mice. Methods: Picrotoxin and strychnine were used for inducing chemoconvulsions in mice. The onset, duration, nature, severity of convulsions and mortality were observed. The severity of convulsions was assessed by scoring method. Results: Picrotoxin and strychnine produced convulsions in higher doses but not in lower doses. Prior administration of G. biloba extract potentiated the action of picrotoxin and strychnine respectively. Conclusion: The potentiation of picrotoxin action by G. biloba indicates the involvement of GABAergic system and chloride channel. Facilitation of strychnine action by G. biloba indicates the modulating effect of the extract on glycine.


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