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Year : 1997  |  Volume : 29  |  Issue : 3  |  Page : 194-197

The anticonvulsant effect of pentazocine against maximal electroshock seizure in mice

Correspondence Address:
Manocha Anshu

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Source of Support: None, Conflict of Interest: None

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Objectives: The present study was designed to investigate whether pentazocine protects against electrically-Induced seizures in mice. An attempt was also made to determine the possible opioid receptor mechanism involved. Methods: Maximal electroshock (MES) seizures were induced in mice via transauricular electrodes (60 mA, 0.2 sec). Seizure severity was assessed by the duration of hindlimb extensor phase. Results: lntraperitoneal administration of pentazocine resulted in a dose dependent inhibition of the hind-limb extensor phase during the MES. The ED50for the effect was found to be 15 mg/kg. The anticonvulsant effect of pentazocine was completely antagonized by the high doses (1.O mg/kg, 5.0/kg), but not by the low doses (0.1 mg/kg, 0.25mg/kg) of i.p. naloxone. Conclusion: The results suggest that the anti-MES effect of pentazocine is mediated by k-receptors, since naloxone in high doses is known to block these receptors.


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