IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 773 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded144    
    Comments [Add]    

Recommend this journal


Year : 1997  |  Volume : 29  |  Issue : 3  |  Page : 190-193

Modulatory role of central purinergic neurotransmitters on Brewer’s yeast-induced inflammation in rats

Correspondence Address:
S K Hore

Login to access the Email id

Source of Support: None, Conflict of Interest: None

Rights and PermissionsRights and Permissions

Objective: To study the effect of centrally administered adenosine, ATP and caffeine on Brewer's yeast-induced peripheral inflammation and nociception in rats Methods: ICV cannulation was performed in rats. ATP (50 'g), adenosine (50 'g) and caffeine (20 'g) were administered centrally, 30 min before administration of phlogistic agent. Acute inflammation was induced by administration of Brewer's yeast suspension below the plantar aponeurosis of hind paw of rats. The hind paw oedema volume and pain threshold were measured by plethysmometer and analgesiometer respectively. Results: ATP showed significant inhibition of Brewer's yeast-induced pedal oedema with concomitant reduction of protein content of exudate. However, adenosine, in addition attenuated pain. Caffeine did not alter the oedema volume, protein content of the exudate or pain threshold. Conclusion: The present study suggests that central purinergic system exerts anti-inflammatory effect and confirms the involvement of CNS in modulating peripheral inflammation.


Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer | Privacy Notice
Online since 20th July '04
Published by Wolters Kluwer - Medknow