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Year : 1997  |  Volume : 29  |  Issue : 3  |  Page : 187-189

Sound stress-induced changes and their modification by drugs in albino rats: an experimental study

Correspondence Address:
A Gehlot

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Source of Support: None, Conflict of Interest: None

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Objective: To study sound stress-induced changes and their modification by drugs in albino rats. Methods: Sound stress of 100 dB ˝ 5 for 30 min was produced by electric bells. Serum glutamate oxaloacetate transaminase (SGOT), Serum glutamate pyruvate transaminase (SGPT), Serum cholesterol levels, serum triglycerides and blood glucose levels were estimated using Miles India Ltd. Kits. His-topathological studies of adrenalskidneys and myocardium were also undertaken. Results: Sound stress caused significant increase in SGOT, SGPT and serum cholesterol levels and significant reduction in serum triglyceride level. Pretreatment with diazepam (DZ)/propranolol (Prop) modified biochemical, enzymological and histological changes in animals exposed to sound stress. Conclusion: The protective/preventive effect of DZ/Prop in this experiment is attributed to their ability to inhibit stress-induced activation of HPA-axis and sympathetic stimulation and functional alteration of cell membranes due to steroidal storm.


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