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Year : 1997  |  Volume : 29  |  Issue : 3  |  Page : 178-181

Anti-inflammatory and analgesic actions of 4’,5,6-trihydroxy-3’7-dimethoxy flavone-from Vicoa indica DC

Correspondence Address:
M Krishnaveni

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Source of Support: None, Conflict of Interest: None

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Objective: To evaluate the antiinflammatory-analgesic property of the 4',5,6-trihydroxy-3',7-dimethoxy-flavone from Vicoa indica DC using different agents and models. Methods: Antiinflammatory effects were produced by different inflammatory agents and after 4 hours the hind paw of the animals were sacrified and weighed in a torsion balance. Analgesic effects were assessed by using different models and by acetic acid. In the former the analgesic effect was noted for a stipulated period of time and in the latter the writhings was counted for 15 minutes. Results: The drug 4', 5, 6-trihydroxy-3',7-dimethoxyflavone at 50 mg/kg body weight was very effective in producing inhibition in both antiinflammatory-analgesic models. Conclusion: This drug recorded consistent inhibitory and antiodema effects in the different agents used for the study.


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