| RESEARCH PAPER
|Year : 1997 | Volume
| Issue : 2 | Page : 99-104
Antihypertensive effect of dietary calcium and diltiazem, a calcium channel blocker on experimentally induced hypertensive rats
SP Rathod, N Shah, R Balaraman
Objective: To determine antihypertensive effect of supplemental dietary calcium alone or in combination with diltiazem in eperimentally induced hypertensive rats.
Methods: In the first set of experiment rats were fed with calcium enriched diet (CED 2%). BP and pressor response to NA and ADR were recorded. In the second set of experiment hypertensive rats (DOCA, CdCl2 or estrogen) treated with CED were recorded for BP and pressor response to NA and ADR. In the third set of experiment hypertensive rats treated with CED and diltiazem were recorded for BP and pressor response to NA and ADR.
Results: Chronic administration of 2% CED (daily for 8 weeks) alone or in combination with diltiazem produced a significant reduction in BP of normal and hypertensive (DOCA, CdCl2, EO) rats. The pressor response to NA and ADR were significantly reduced in CdCl2 treated rats fed with 2% CED and there was a significant decrease in pressor response to NA and ADR in hypertensive rats treated with diltiazem and 2% CED.
Conclusion: Supplemental dietary calcium may bring about stabilisation of ionic fluxes and decrease the abnormal intracellular calcium level implicated in hypertension while combination of CED with diltiazem produced additive antihypertensive effects.
S P Rathod
Source of Support: None, Conflict of Interest: None