| RESEARCH PAPER
|Year : 1997 | Volume
| Issue : 2 | Page : 86-91
Effect of hypertension and anti-antihypertensive agents on haemostatic variables
Nayak K Vidyagauri, NK Desai, KC Gupta
Objectives: The present study was carried out in normal subjects (89 in number) and hypertensive patients (118 in number) to evaluate the effects of hypertension per se and the antihypertensive agents on haemostatic variables.
Methods: Haemostatic variables like prothrombin time, partial thromboplastin time, thrombin clotting time, heparin thrombin clotting time, Factors VII and VIII, fibrinogen, platelet count, platelet aggregation, euglobulin clot lysis time and antithrombin Ill were estimated in normal subjects. freshly detected hypertensives and the patients already receiving treatment with various antihypertensive agents. The tests were repeated in the freshly detected cases after six months therapy.
Results: Freshly detected hypertensive patients were found to have abnormalities in some of the haemostatic variables such as increased factor VIII (mean ˝ SE; 116.71 ˝ 3.69%), reduced PT (14.83 ˝ 0.25 secs) and HTCT (24.50 ˝ 0.93 secs) values. On the other hand in the patients already receiving treatment PTT-K values were reduced (36.76 ˝ 1.16 secs) and factor VIII (118.12 ˝ 2.22%) and fibrinogen levels (512.32 ˝ 11.82 mg%) increased compared to normals. Fibrinolytic activity was also reduced in both the groups with values of ECLT being 196.91 ˝ 10.66 and 197.20 ˝ 7.27 mins. respectively and ATIII levels being 73.12 ˝ 2.72% and 73.77 ˝ 2.72% respectively compared to normals. While PAT with ADP was significantly increased (52.33 ˝ 2.68%) in freshly detected patients, PAT with collagen was significantly reduced (40.51 ˝ 1.96%) in patients already receiving treatment. Platelet counts were also high in these two groups with the values being 206.42 ˝ 7.02 x l03 cumm and 195.45 ˝ 2.91 x 10 3 cumm respectively.
Conclusion: The study suggests that there could be an increased risk of thromboembolic complications in hypertensive patients. Therefore, there is a need to monitor the haemostatic variables in hypertensive patients in order to prevent thrombogenic complications.
Nayak K Vidyagauri
Source of Support: None, Conflict of Interest: None