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 RESEARCH PAPER
Year : 1997  |  Volume : 29  |  Issue : 2  |  Page : 76-81

Protective role of propolis against alcohol carbon tetrachloride-induced hepatotoxicity in rats



Correspondence Address:
M Sharma


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Source of Support: None, Conflict of Interest: None


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Objectives: The present study is aimed at finding the effect of propolis (a natural resin produced by honey bees, rich in flavonoids) in a model of hepatotoxicity produced by alcohol and carbon tetrachloride (CCl4) in vivo. Methods: The effect of intraperitoneal (i.p.) administration of propolis (50 and 100 mg/kg) was studied on hepatotoxicity produced by alcohol (40%, 2.0 ml/100 gm, p.o for 21 days) and CCl4 1:1 in groundnut oil 0.1 ml/kg, S.C. on 20th day. Serum transaminases, alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood and tissue glutathione (GSH) and thiobarbituric acid reactive substances (TBARS) in liver were estimated following the established procedures to assess the liver function. Biochemical observations were supplemented with histological examination of liver sections. Results: ALT and AST which were elevated by alcohol and CCl4 (68.39 ˝ 1.87 and 65.89 ˝ 0.75 IU/L) were lowered to physiological levels (39.33 ˝ 0.90 and 40.66 ˝ 0.51 IU/L) by co-administration of propolis. Glutathione (GSH) that was reduced significantly in blood and liver (0.036 ˝ 0.05 mg% and 7.34 ˝ 0.043 'moles/gm tissue) was brought back to near normal level (0.925 ˝ 0.04 mg% and 9.03 ˝ 0.09 'moles/gm tissue). The lipid peroxides were increased (1.93 ˝ 0.15 nmoles MDA/mg protein) in alcohol and CCl4 treated group. Propolis reduced the lipid peroxides level (1.02 ˝ 0.03 nmoles MDA/mg protein) in liver. Multifocal necrotic changes of liver by CCl4 and alcohol treatment were minimised to near normal morphology by propolis. Conclusion: Propolis showed a dose dependent protective effect on alcohol and CCl4 induced hepatotoxicity. The effect was more pronounced in 100 mg/kg propolis treated rats and was comparable with a standard hepatoprotective preparation, Liv.52.






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