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Year : 1997  |  Volume : 29  |  Issue : 2  |  Page : 135-137

Comparative bioavailability of two brands of cyclosporin

Correspondence Address:
A Sachdeva

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Source of Support: None, Conflict of Interest: None

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Objectives: To compare the pharmacokinetics of two brands of oral cyclosporin solution was compared in healthy male volunteers. Methods: A single oral dose of 15mg/kg of either test or reference preparations of cyclosporin was administered to all the volunteers in double blind randomised cross over fashion. Plasma levels of cyclosporin were analysed using HPLC. Results: The mean peak plasma cyclosporin concentration of 654.4ng/ml was observed at 3.39h with test brand and was similar to that of reference brand with Cmax of 628.61ng/ml at 3.43h. The differences between the pharmacokinetic parameters of two brands of cyclosporin were statistically in significant. Conclusion: Both the brands of cyclosporin can be considered to be bioequivalent on the basis of the results obtained.


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