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Year : 1997  |  Volume : 29  |  Issue : 2  |  Page : 132-134

Preliminary study on anti-inflammatory effect of calcium channel blockers in albino rats

Correspondence Address:
G N Aditya

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Source of Support: None, Conflict of Interest: None

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Objectives: To study the anti-inflammatory effect of nifedipine, verapamil and diltiazem on carrageenin-induced hind paw oedema and granuloma pouch in rats. Methods: Hind paw oedema was produced by subplantar injection of 0.1 ml of freshly prepared 1% suspension of carrageenin in normal saline and paw volume was measured plethysmometrically at 0 hour and 3 hours after carrageenin injection. Granuloma pouch was produced by the injection of 4 ml of 2% (w/v) carrageenin in sterile normal saline in the nape of the neck. The animals were sacrificed on the sixth day and the volume of pouch fluid and wet weight of granulation tissue were measured. Results: Nifedipine, verapamil and diltiazem produced significant and dose-dependent anti-inflammatory effect in rat hind paw oedema and were found to be more potent as compared to aspirin. Nifedipine produced significant inhibition of the volume of the pouch fluid and weight of the granulation tissue in granuloma pouch. Verapamil and diltiazem produced no significant effect. Conclusion: Nifedipine has anti-inflammatory effect both in acute and chronic inflammation, Verapamil and diltiazem possess anti-inflammatory effect only in acute inflammation,


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