IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 1183 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded82    
    Comments [Add]    

Recommend this journal


Year : 1997  |  Volume : 29  |  Issue : 2  |  Page : 125-128

Nitric oxide modulation of cardiovascular responses from ventral surface of medulla in cat

Correspondence Address:
S Verma

Login to access the Email id

Source of Support: None, Conflict of Interest: None

Rights and PermissionsRights and Permissions

Objectives: To analyse the functional significance of Nitric oxide (NO) in cardiovascular regulation from rostral ventral medulla in cats using nitric oxide precursor, donor and guanylate cyclase inhibitor, methylene blue. Methods: Arterial pressure was recorded from femoral artery of chloralose anaesthetized cats through statham P23 DC transducer on Grass model P7 polygraph and the heart rate was also triggered using Grass 7P4 tac hograph. The effect on blood pressure and heart rate was monitored following topical application of NO precursor, L-Arg (1,2 and 5% for 10 minutes), NO donor, sodium nitroprusside (SNP) (0.1 and 0.5% for 10 minutes) and methylene blue (MB) (1% for 10 minutes) on exposed rostro-ventral medulla. Results: L-Arginine (1,2 and 5%) did not produce significant effects on blood pressure and heart rate. However, topical application of SNP ( O.1%-0.5%) produced significant hypotension and bradycardia which was attenuated by guanylate cyclase inhibitor methylene blue. Conclusion:The significant hypotension and bradycardia produced by SNP and blockade by methylene blue suggests the possible involvement of NO-cGMP mechanism in central cardiovascular regulation.


Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer | Privacy Notice
Online since 20th July '04
Published by Wolters Kluwer - Medknow