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Year : 1997  |  Volume : 29  |  Issue : 2  |  Page : 117-124

Diflunisal affects chick embryo neural tube development - an action not mediated by prostaglandins

Correspondence Address:
Kotwani Anita

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Source of Support: None, Conflict of Interest: None

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Objectives: Aspirin has been shown to produce defect in neural tube development in chick embryo and this effect could be antagnozied by pre-treatment with PGF2(. Diflunisal inhibits prostaglandin synthesis and is likely to be used during pregnancy. Hence, the present work was undertaken to find out whether like aspirin, diflunisal also affects neural tube development in chick embryo. Methods: (i) Diflunisal in four doses, viz. 3. 6, 30 and 60'g/embryo was injected sub-blastodermally by window technique in fresh embryonated eggs after 17 hours of incubation at 39(0.5(C. Eggs were re-incubated and harvested at 40 hours (ii) Effect of PGEI (5'g) and PGF2(, (5'g) was studied on the defect induced by diflunisal (6'g) (iii) Effect of diflunisal (6'g) and aspirin (30'g) was studied at different time intervals uptil neural tube formation i.e., drugs were injected at 17 hours and embryos were harvested at 22 hours, 27 hours and 40 hours. Results: All the four doses of diflunisal produced significant changes in neural tube development of chick embryo. PGE1 and PGF2( treatment potentiated the effect of diflunisal. Aspirin induced neural tube defect was seen at 22 hours and remained same till 40 hours, whereas it was observed that effect of diflunisal was delayed it could be observed at 40 hours. Conclusion: Diflunisal, produces neural tube defect in chick embryo but this action is not mediated by prostaglandins. may be it acts at some other cellular level which requires some time for its action.


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