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Year : 1997  |  Volume : 29  |  Issue : 2  |  Page : 110-116

Anti-inflammatory and hepatoprotective activities of Sida rhombifolia Linn

Correspondence Address:
Rao S Kumar

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Source of Support: None, Conflict of Interest: None

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Objectives: To study the effects of different parts of Sida rhombifolia on chemical and drug induced hepatotoxicants and on carrageenan induced paw oedema in rats. Methods: Hepatotoxicity was induced in rats by treatment with carbon tetrachloride, paracetamol and rifampicin and the hepatoprotective activity was measured by determining various enzymes and bilirubin levels in serum. Oedema was induced by carrageenan and the oedema suppressant activity was measured using a plethysmometer. Results: The powdered roots aerial parts and their aqueous extract showed significant hepatoprotective activity. The methanolic extract of the aerial parts showed significant oedema suppressant activity in rats. Conclusion: The hepatoprotective activity of the powdered drug and its extract may be due the stimulatory effects on hepatic regeneration or free radical scavenging effects, etc. The oedema suppressant activity the drug may be due to the inhibitory effects on the release of histamine like substances.


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