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 RESEARCH PAPER
Year : 1997  |  Volume : 29  |  Issue : 2  |  Page : 105-109

Cell culture derived Hemidesmus indicus in the prevention of hypercholesterolemia in normal and hyperlipidemic rats



Correspondence Address:
K N Bopanna


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Objectives: To study the effect of cell culture extract of Hemidesmus indicus (CCH) on normal and hypercholesterolemic rats for various lipid profile in serum, tissues and fecal matter. Methods: Twelve groups of eight animals were subgrouped into three set of experiments. First group received normal and CCH (2, 4 and 16 mg/kg, p.o.) for 30 days, second group received atherogenic diet for 30 (l-30) days and CCH (2, 4 and 16 mg/kg, p.o.) for next 30 (31-60) days, third group received atherogenic diet and CCH (2,4 and 16 mg/kg, p.o.) for 60 days concurrently. Serum tissue and faecal lipid profile were analysed. Results: It was observed that the CCH (2, 4, and 16 mg/kg, p.o.) had prevented hypercholesterolemia in rats. Rats which received atherogenic diet for first 30 (l-30) days when subjected to CCH (2, 4 and 16 mg/kg, p.o.) for next 30 (31-60) days showed significant treatment reduction (p<0.01) of lipid levels in serum. When atherogenic diet and CCH were given together for 60 (l-60) days there was significant (p<0.01) reduction of lipid in liver, heart and serum fecal excretion of cholesterol and phospholipids were significantly increased (p<0.01 in rats fed with CCH. Conclusion: Atherogenic diet along with CCH concurrently lowered the levels of serum, tissue and fecal lipid levels.






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