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Year : 1997  |  Volume : 29  |  Issue : 1  |  Page : 24-64

Abstracts of research papers accepted for presentation at the XXIX National Conference of Indian Pharmacological Society, December 20-22, 1996, Hyderabad

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Objectives: To assess the incidence of adverse drug reactions due to ranitidine, famotidine omeprazole and their effect on hepatic function tests and lipid profile in a sample Delhi population. Methods: A prospective study was done in 170 patients diagnosed as acid peptic disease, attending medicine outpatient clinic of Lok Nayak Jai Prakash Narayan Hospital, New Delhi. They were prescribed one of the following drugs, ranitidine (300 mg total daily dose), famotidine (40 mg total daily dose) or omeprazole (20-40 mg total daily dose) and followed every two weeks for twelve weeks. At each visit patients were observed for subjective and objective side effects. Dechallenge was done for any observed side effect. Hepatic function tests and lipid profile were conducted at baseline, four. eight and twelve weeks. Results: Three patients (7.5%) on ranitidine reported adverse drug reactions. These included two cases (5%) of diarrhoe and one case (2.5%) of skin rashes on the extremities. No adverse drug reactions were observed with famotidine and omeprazole. No significant alteration in hepatic function tests and lipid profile at twelve weeks were observed with any of the test drugs. Conclusion: Incidence of adverse drug reactions with famotidine and omeprazole is low. Ranitidine, famotidine and omeprazole have no significant effects on hepatic functions and lipid profile when used for a period of twelve weeks


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