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Year : 1996  |  Volume : 28  |  Issue : 4  |  Page : 265-268

Antiulcerogenic effect of UL-409 against experimentally induced gastric ulcer in rats

Correspondence Address:
A J Vanisree

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Source of Support: None, Conflict of Interest: None

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An aqueous suspension of a herbal drug formulation (UL-409) was tested in male Wistar rats for antiulcerogenic activity. The drug formulation displayed cytoprotective action against experimentally induced peptic ulcer. A daily dose of 600 mg/kg body weight of the formulation orally for 30 days decreased the number of ulcerative lesions, prevented the increased lipid peroxidation and enhanced the activities of antioxidant enzymes namely, superoxide dismutase, catalase and glutathione peroxidase along with the reduction in the consumption of glutathione. Since UL-409 reduced the damage caused by HCl/ethanol and increased the activities of scavenging enzymes, it is concluded that its antiulcerogenic activity is mediated through antioxidant defense mechanism.


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