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Year : 1996  |  Volume : 28  |  Issue : 4  |  Page : 254-256

Impairment of glycerol 3-phosphate shuttle by methyl isocyanate in rats

Correspondence Address:
K Jeevaratnam

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Source of Support: None, Conflict of Interest: None

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The present study describes the effect of methyl isocyanate (MIC) on the hepatic glycerol 3-phosphate shuttle. Addition of MIC to the isolated rat liver mitochondria in vitro resulted in a dose-dependent inhibition of glycerol 3-phosphate dehydrogenase. Subcutaneous ad-ministration of MIC at lethal dose to rats caused a significant effect on hepatic glycerol 3- phosphate shuttle. There was a significant inhibition of both mitochondrial and cytosolic glycerol 3-phosphate dehydrogenase indicating the impairment of translocation of the reducing equivalents, NADH into the mitochondria.


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