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Year : 1996  |  Volume : 28  |  Issue : 3  |  Page : 188-190

The modulating effect of glutathione on lipid peroxidation in rats treated with anticancer drugs and x-ray irradiation

Correspondence Address:
G Muralikrishnan

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Source of Support: None, Conflict of Interest: None

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The protective effect of glutathione was assessed against cytotoxic antitumour agents like cyclophosphamide, methotrexate, 5-fluorouracil (CMF) and X-ray irradiated rats. Glutathione supplementation into the CMF and X-ray irradiated rats showed decrease in the level of thiobarbituric acid reacting substances (TBARS) in plasma, liver and intestine. It was increased in the lung even after receiving the glutathione. The level of antioxidant enzymes were restored in the RBC hemolysate.


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