| RESEARCH PAPER
|Year : 1996 | Volume
| Issue : 3 | Page : 181-184
Evaluation of clinical efficacy and safety of hydroxyethyl starch
Rani P Usha, MUR Naidu, Rao S Manimala, VSSN Murthy, Kumar T Ramesh, JC Shobha, Kumar T Vijay
Hydroxyethyl starch (HES) 6% has been shown to improve hypovolaemia, with minimum side effects and long duration of action. Thirty patients showing signs of hypovolaemia post-operatively, in the form of tachycardia and hypotension received 500 ml of 6% HES intravenously over 30-60 minutes. Administration of HES, significantly improved hypovolaemia in all the patients. Within 30 minutes after infusion, systolic blood pressure (SBP) increased from 85˝ 6 to 98˝ 8 mm Hg. Heart rate decreased from 124˝ 3 beats per minute (bpm) to 99˝ 6 bpm and central venous pressure (CVP) increased from 1˝ 1 to 3.5k1.2 cm of saline, at one hour post HES administration. This improvement persisted till the end of sixth hour observation period. All patients tolerated HES well without any side effects and hematological or biochemical abnormalities.
Rani P Usha
Source of Support: None, Conflict of Interest: None