IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 1815 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded89    
    Comments [Add]    

Recommend this journal


Year : 1996  |  Volume : 28  |  Issue : 3  |  Page : 155-160

Synthetic peptides related to S-receptor agonist dermorphin gene associated peptide

Correspondence Address:
K M Sivanandiah

Login to access the Email id

Source of Support: None, Conflict of Interest: None

Rights and PermissionsRights and Permissions

Five peptides related to the b-receptor agonist, dermorphin gene associated peptide (DGAP), having structural modifications at the positions 2, 6 and 7 were synthesised by the solid phase method using 9-fluorenylmethoxycarbonyl amino acid trichlorophenyl esters as coupling agents and p-alkoxybenzyl alcohol resin as the solid support. The biological activities of these peptides were determined in vitro using guinea pig ileum and mouse vas deferens assays and in vivo employing the analgesic and antidiarrhoeal assays. The S-receptor selectivity was determined by the ratio of IC50 values in the MVD assay to that of the GPI assay and all the synthetic peptides were found to possess b-receptor selectivity; [Nva6] DGAP being the most selective in the present series. [Eth6] DGAP exhibits a higher selectivity with regard to analgesic to antidiarrhoeal activity in the in vivo assay.


Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer | Privacy Notice
Online since 20th July '04
Published by Wolters Kluwer - Medknow