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Year : 1996  |  Volume : 28  |  Issue : 3  |  Page : 152-154

Effect of isoproturon on barbiturate induced hypnosis in mice

Correspondence Address:
Kumar Vinod

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Source of Support: None, Conflict of Interest: None

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lsoproturon a herbicide produces a CNS depressant effect. Pretreatment of mice with isoproturon at different doses increased the duration of pentobarbitone induced sleep in mice and potentiated the effect of subhypnotic dose of pentobarbitone. lsoproturon also decreased the onset and increased the duration of barbitone induced sleep in mice. However, four days pretreatment with two divided doses of isoproturon significantly decreased the duration of sleep and increased the mean liver weight in mice. The results indicate that isoproturon might have direct CNS depressant action. Decrease in pentobarbitone sleeping time in isoproturon pretreated mice appears to be due to induction of hepatic microsomal enzymes.


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