| RESEARCH PAPER |
|
| Year : 1996 | Volume
: 28
| Issue : 2 | Page : 88-92 |
Optimizing dosage regimens of liposomal amphotericin B using aspergillus murine model
RN Kotwani, PC Gokhale, NA Kshirsagar, SK Pandya
Correspondence Address:
R N Kotwani
 Source of Support: None, Conflict of Interest: None  | Check |
Amphotericin B remains the drug of choice in most systemic mycoses, but its use is often limited by its severe side effects. Liposomal encapsulation of amphotericin B has been shown to improve tolerance without compromising efficacy. In this study, the dosage regimens and frequency of administration of liposomal amphotericin B prepared using soya phosphatidylcholine and cholesterol given prophylactically or therapeutically in mice infected with Aspergillus fumigatus was assessed. Liposomal amphotericin B was more effective than free amphotericin B on an equal dose basis when given therapeutically. A large single dose of liposomal amphotericin B was more effective, both prophylactically and therapeutically, than two divided doses of the total dose.
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