| RESEARCH PAPER
|Year : 1996 | Volume
| Issue : 2 | Page : 88-92
Optimizing dosage regimens of liposomal amphotericin B using aspergillus murine model
RN Kotwani, PC Gokhale, NA Kshirsagar, SK Pandya
Amphotericin B remains the drug of choice in most systemic mycoses, but its use is often limited by its severe side effects. Liposomal encapsulation of amphotericin B has been shown to improve tolerance without compromising efficacy. In this study, the dosage regimens and frequency of administration of liposomal amphotericin B prepared using soya phosphatidylcholine and cholesterol given prophylactically or therapeutically in mice infected with Aspergillus fumigatus was assessed. Liposomal amphotericin B was more effective than free amphotericin B on an equal dose basis when given therapeutically. A large single dose of liposomal amphotericin B was more effective, both prophylactically and therapeutically, than two divided doses of the total dose.
R N Kotwani
Source of Support: None, Conflict of Interest: None