| SHORT COMMUNICATION |
|
| Year : 1996 | Volume
: 28
| Issue : 2 | Page : 120-122 |
Synthesis and preliminary cardiovascular activity of some phenoxypropanolamines as beta blockers
J Kannan, R Giridhar, R Balaraman
Correspondence Address:
J Kannan
 Source of Support: None, Conflict of Interest: None  | Check |
Three compounds of phenoxypropanolamine type with chlorine substituted at para (Compound I: PCP) and ortho (Compound II: OCP) positions and without chlorine (Compound III: NCP) were synthesised and characterised by their physical and chemical methods. All the three compounds significantly (P<0.001) reduced the tachycardia induced by isoprenaline in dogs and rats while compound I and compound II significantly (P<0.001) blocked the isoprenaline induced fall in blood pressure implying a non-selective beta, and beta, blocking effect in both species. Compound III did not block the isoprenaline induced fall in blood pressure in both the animals implying a selective beta, action. The blockade produced by compound I & II (2 x 10-6 M) were similar to the effect produced by propranolol (2 x 10-6 M).
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