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Year : 1996  |  Volume : 28  |  Issue : 2  |  Page : 120-122

Synthesis and preliminary cardiovascular activity of some phenoxypropanolamines as beta blockers

Correspondence Address:
J Kannan

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Source of Support: None, Conflict of Interest: None

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Three compounds of phenoxypropanolamine type with chlorine substituted at para (Compound I: PCP) and ortho (Compound II: OCP) positions and without chlorine (Compound III: NCP) were synthesised and characterised by their physical and chemical methods. All the three compounds significantly (P<0.001) reduced the tachycardia induced by isoprenaline in dogs and rats while compound I and compound II significantly (P<0.001) blocked the isoprenaline induced fall in blood pressure implying a non-selective beta, and beta, blocking effect in both species. Compound III did not block the isoprenaline induced fall in blood pressure in both the animals implying a selective beta, action. The blockade produced by compound I & II (2 x 10-6 M) were similar to the effect produced by propranolol (2 x 10-6 M).


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