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Year : 1996  |  Volume : 28  |  Issue : 2  |  Page : 113-115

Effects of chronic treatment of rat with ethinyl estradiol on the sensitivity of isolated vascular preparations to nor-adrenaline

Correspondence Address:
J D Bhatt

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Source of Support: None, Conflict of Interest: None

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In the present study, ethinyl estradiol (EE) was administered chronically at a dose of 1.5 mg/ kg/ day intramuscularly to rats for 3 weeks and the sensitivity of isolated aortic strip and portal vein to nor-adrenaline (NA) was studied. Chronic EE treatment did not alter the pD2 values of NA in isolated aortic strip; however, it produced significant increase in pD2 values of NA in portal vein preparation. Chronic EE treatment did not alter the aortic relaxation. It is concluded that chronic EE treatment of rat results in supersensitivity of portal vein to NA, which may be prejunctional in nature.


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