| SHORT COMMUNICATION |
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| Year : 1996 | Volume
: 28
| Issue : 2 | Page : 110-112 |
Contractile activity of Alstonia boonei stem bark extract on isolated rat stomach strip and guinea pig ileum
JM Makinde, OB Taiwo
Correspondence Address:
J M Makinde
 Source of Support: None, Conflict of Interest: None  | Check |
The effect of lyophylized aqueous extract of Alstonia boonei stem bark was investigated on guinea pig ileum and rat stomach strip. The extract had a contractile effect on both smooth muscles; the effect was more on rat stomach strip than on guinea pig ileum. Pre-incubation of the stomach strip preparation did not inhibit the extract induced tonic contractions. On the other hand, the contraction induced by the extract was antagonised by methysergide in a competitive manner suggesting a role for 5-HT in the biological effect of the extract.
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