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Year : 1996  |  Volume : 28  |  Issue : 2  |  Page : 110-112

Contractile activity of Alstonia boonei stem bark extract on isolated rat stomach strip and guinea pig ileum

Correspondence Address:
J M Makinde

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Source of Support: None, Conflict of Interest: None

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The effect of lyophylized aqueous extract of Alstonia boonei stem bark was investigated on guinea pig ileum and rat stomach strip. The extract had a contractile effect on both smooth muscles; the effect was more on rat stomach strip than on guinea pig ileum. Pre-incubation of the stomach strip preparation did not inhibit the extract induced tonic contractions. On the other hand, the contraction induced by the extract was antagonised by methysergide in a competitive manner suggesting a role for 5-HT in the biological effect of the extract.


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