| SHORT COMMUNICATION
|Year : 1996 | Volume
| Issue : 2 | Page : 110-112
Contractile activity of Alstonia boonei stem bark extract on isolated rat stomach strip and guinea pig ileum
JM Makinde, OB Taiwo
The effect of lyophylized aqueous extract of Alstonia boonei stem bark was investigated on guinea pig ileum and rat stomach strip. The extract had a contractile effect on both smooth muscles; the effect was more on rat stomach strip than on guinea pig ileum. Pre-incubation of the stomach strip preparation did not inhibit the extract induced tonic contractions. On the other hand, the contraction induced by the extract was antagonised by methysergide in a competitive manner suggesting a role for 5-HT in the biological effect of the extract.
J M Makinde
Source of Support: None, Conflict of Interest: None