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Year : 1996  |  Volume : 28  |  Issue : 1  |  Page : 29-31

Pro-inflammatory and pro-algesic effect of icv administered Substance P in rats

Correspondence Address:
V K Dumka

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Source of Support: None, Conflict of Interest: None

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The central modulatory role of substance P following its icv administration (50 'g) was studied on formaldehyde-induced paw oedema and nociception in rats. A significant accentuation of oedema volume was shown along with proalgesic effect on formaldehyde-induced inflammation. A corresponding increase was also observed in protein content of the inflammatory exudate. The study confirms the pro inflammatory effect of substance P.


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