| SHORT COMMUNICATION |
|
| Year : 1996 | Volume
: 28
| Issue : 1 | Page : 29-31 |
Pro-inflammatory and pro-algesic effect of icv administered Substance P in rats
VK Dumka, SK Tandan, HC Tripathi, V Raviprakash
Correspondence Address:
V K Dumka
 Source of Support: None, Conflict of Interest: None  | Check |
The central modulatory role of substance P following its icv administration (50 'g) was studied on formaldehyde-induced paw oedema and nociception in rats. A significant accentuation of oedema volume was shown along with proalgesic effect on formaldehyde-induced inflammation. A corresponding increase was also observed in protein content of the inflammatory exudate. The study confirms the pro inflammatory effect of substance P.
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