IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 1783 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 ╗   Next article
 ╗   Previous article
 ╗   Table of Contents

Resource Links
 ╗   Similar in PUBMED
 ╗  Search Pubmed for
 ╗  Search in Google Scholar for
 ╗Related articles
 ╗   Citation Manager
 ╗   Access Statistics
 ╗   Reader Comments
 ╗   Email Alert *
 ╗   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded173    
    Comments [Add]    

Recommend this journal


Year : 1996  |  Volume : 28  |  Issue : 1  |  Page : 25-28

Effect of aspirin on single and multiple dose pharmacokinetics of ciprofloxacin in rabbits

Correspondence Address:
V Parikh

Login to access the Email id

Source of Support: None, Conflict of Interest: None

Rights and PermissionsRights and Permissions

The alteration caused by aspirin treatment in various single and multiple dose pharmacokinetic parameters of cirprofloxacin has been studied in rabbits. In the single dose study, seven days of aspirin (300 mg/kg) bid pretreatment tended to prolong elimination half-life at the terminal phase (t1/2() (209.63˝ 114.10 mins Vs 312.25˝ 189.65 min, P > 0.05) and reduce the total body clearance (CL) (202.59˝ 81.45 ml/min Vs 145.11˝ 48.88 ml/min, P > 0.05) of ciprofloxacin hydrochloride (5 mg/kg). In the multiple dose study, co-administration of aspirin (300 mg/kg) bid with ciprofloxacin hydrochloride (5 mg/kg) for seven days produced insignificant changes in the pharmacokinetic parameters except the average serum ciprofloxacin concentration on the seventh day (Cmax) (10.60˝ 1.50 10-2 'g/ml) as compared to (7.60˝ 1.70 10-2 'g/ml )in the control group given ciprofloxacine alone for the same duration. There is a possibility that competitive inhibition of elimination process of ciprofloxacin by aspirin may be the cause of significant increase in its serum levels.


Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer | Privacy Notice
Online since 20th July '04
Published by Wolters Kluwer - Medknow