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Year : 1995  |  Volume : 27  |  Issue : 4  |  Page : 241-244

Predominant GABA-B mediated dispersion of the isolated web Melanophores of the Indian bull frog, Rana tigerina(Daud.)

Correspondence Address:
S R Chimania

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Source of Support: None, Conflict of Interest: None

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Effect of GABA-ergic agonists on the isolated web melanophores of a frog (Rana tigerina) was examined. Melanophore size index (MSI) was employed as a recording parameter for the responses of the melanophores to drugs. GABA and baclofen both induced strong dispersion in the frog melanophores. Propranolol and 5-aminovaleric acid significantly inhibited the dispersion of frog melanophores induced by GABA and baclofen, while bicuculline failed to inhibit the dispersal responses of the melanophores significantly. It is indicated that the disoersion of the froa melanoohores induced by GABA-ergic agonists is mediated predomi nantly through GABAB receptors.


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