| RESEARCH PAPER
|Year : 1995 | Volume
| Issue : 4 | Page : 222-226
Disposition kinetics of sulphamethoxypyridazine during endotoxin induced fever and its modification by sodium salicylate in goats
S Juliet, A Barman, S Majumder, TK Mandal, AK Chakraborty
Disposition kinetics of sulphamethoxypyridazine (25 mg/kg, i.v.) in absence and in presence of sodium salicylate (50 mg/kg, i.v.) in both afebrile and endotoxininduced febrile conditions were studied in female black Bengal goats. The disposition kinetics of sul phamethoxypyridazine alone and in presence of sodium salicylate were described by a two compartment and one compartment model respectively. Sulphamethoxypyridazine persisted in afebrile and febrile goats till 36 and 24 h post administration, while in presence of sodium salicylate it persisted till 30 and 24 h in afebrile and febrile goats. Sodium salicylate decreased the plasma protein binding activity of sulphamethoxypyridazine. Besides, sodium salicylate decreased the t1/2(() , Vd(area) (P < 0.01); and increased the AUC value of sulphamethoxy-pyridazine.
Source of Support: None, Conflict of Interest: None