IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 1853 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1506    
    Printed78    
    Emailed0    
    PDF Downloaded129    
    Comments [Add]    

Recommend this journal

 

 RESEARCH PAPER
Year : 1995  |  Volume : 27  |  Issue : 4  |  Page : 222-226

Disposition kinetics of sulphamethoxypyridazine during endotoxin induced fever and its modification by sodium salicylate in goats



Correspondence Address:
S Juliet


Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

Disposition kinetics of sulphamethoxypyridazine (25 mg/kg, i.v.) in absence and in presence of sodium salicylate (50 mg/kg, i.v.) in both afebrile and endotoxininduced febrile conditions were studied in female black Bengal goats. The disposition kinetics of sul phamethoxypyridazine alone and in presence of sodium salicylate were described by a two compartment and one compartment model respectively. Sulphamethoxypyridazine persisted in afebrile and febrile goats till 36 and 24 h post administration, while in presence of sodium salicylate it persisted till 30 and 24 h in afebrile and febrile goats. Sodium salicylate decreased the plasma protein binding activity of sulphamethoxypyridazine. Besides, sodium salicylate decreased the t1/2(() , Vd(area) (P < 0.01); and increased the AUC value of sulphamethoxy-pyridazine.






[PDF]*


        
Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer
Online since 20th July '04
Published by Wolters Kluwer - Medknow