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Year : 1995  |  Volume : 27  |  Issue : 4  |  Page : 222-226

Disposition kinetics of sulphamethoxypyridazine during endotoxin induced fever and its modification by sodium salicylate in goats

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Disposition kinetics of sulphamethoxypyridazine (25 mg/kg, i.v.) in absence and in presence of sodium salicylate (50 mg/kg, i.v.) in both afebrile and endotoxininduced febrile conditions were studied in female black Bengal goats. The disposition kinetics of sul phamethoxypyridazine alone and in presence of sodium salicylate were described by a two compartment and one compartment model respectively. Sulphamethoxypyridazine persisted in afebrile and febrile goats till 36 and 24 h post administration, while in presence of sodium salicylate it persisted till 30 and 24 h in afebrile and febrile goats. Sodium salicylate decreased the plasma protein binding activity of sulphamethoxypyridazine. Besides, sodium salicylate decreased the t1/2(() , Vd(area) (P < 0.01); and increased the AUC value of sulphamethoxy-pyridazine.


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