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Year : 1995  |  Volume : 27  |  Issue : 3  |  Page : 197-200

Influence of aspartic acid and glutamic acid on non-enzymatic glycation of lens proteins in vitro

Correspondence Address:
R Sivakumar

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Source of Support: None, Conflict of Interest: None

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Non-enzymatic glycation seems to be one of the major contributory factors for the conformational loss in the lens proteins, and hence cause diabetic cataract. Here we made a trial to reduce non-enzymatic glycation of lens proteins by acidic amino acids. For this study we relied on the in vitro glycation of goat, rat and human cataractous lens proteins. Lens homogenates were incubated with different concentrations of glucose for 72 hours. The effects of 5 and 10 mM of aspartic acid and glutamic acid were studied individually. The observations of this study indicate that these two amino acids can protect lens proteins from glycation in vitro.


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