| SHORT COMMUNICATION |
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| Year : 1995 | Volume
: 27
| Issue : 3 | Page : 193-194 |
Pharmacokinetic profile of intra-articular lignocaine during knee joint arthroscopy
NR Biswas, NG Mandal, Kumar PGL Lalit
Correspondence Address:
N R Biswas
 Source of Support: None, Conflict of Interest: None  | Check |
Pharmacokinetic parameters of lignocaine after synovial absorption during intra-articular bolus injection were studied. Local anaesthesia technique consisted of local infiltration and intra- articular bolus injection followed by continuous irrigation with adrenaline containing lignocaine solution. Total dose given was 7 mg/kg. Serum levels were measured during and following the procedure to determine peak levels obtained and to assure that toxic levels were not exceeded. Pharmacokinetic parameters determined were (mean ( SD) Cmax, Tmax, Ka and t1/2ab. Lignocaine levels ranged from 0.10 - 2.75 (g/ml with an average peak concentrations of 2.18 r 0.38 (g/ml. No complication of lignocaine toxicity was noted by the anaesthesiologist or the operating surgeon. Results indicated that injection of 7 mg/kg lignocaine intra- articularly during knee arthroscopy produced peak blood concentrations within the first hour of surgery and was considerably low to produce toxicity. This technique was safe well tolerated by all patients and found to be adequate by the surgeon.
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