IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 1690 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded119    
    Comments [Add]    

Recommend this journal


Year : 1995  |  Volume : 27  |  Issue : 3  |  Page : 193-194

Pharmacokinetic profile of intra-articular lignocaine during knee joint arthroscopy

Correspondence Address:
N R Biswas

Login to access the Email id

Source of Support: None, Conflict of Interest: None

Rights and PermissionsRights and Permissions

Pharmacokinetic parameters of lignocaine after synovial absorption during intra-articular bolus injection were studied. Local anaesthesia technique consisted of local infiltration and intra- articular bolus injection followed by continuous irrigation with adrenaline containing lignocaine solution. Total dose given was 7 mg/kg. Serum levels were measured during and following the procedure to determine peak levels obtained and to assure that toxic levels were not exceeded. Pharmacokinetic parameters determined were (mean ( SD) Cmax, Tmax, Ka and t1/2ab. Lignocaine levels ranged from 0.10 - 2.75 (g/ml with an average peak concentrations of 2.18 r 0.38 (g/ml. No complication of lignocaine toxicity was noted by the anaesthesiologist or the operating surgeon. Results indicated that injection of 7 mg/kg lignocaine intra- articularly during knee arthroscopy produced peak blood concentrations within the first hour of surgery and was considerably low to produce toxicity. This technique was safe well tolerated by all patients and found to be adequate by the surgeon.


Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer | Privacy Notice
Online since 20th July '04
Published by Wolters Kluwer - Medknow