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Year : 1995  |  Volume : 27  |  Issue : 3  |  Page : 178-182

Suppression of exploration and locomotion by central nervous system stimulants

Correspondence Address:
A K Agarwal

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Source of Support: None, Conflict of Interest: None

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Exploration and locomotion was studied on a hole-board following intraperitoneal administration of CNS stimulants in mice. Each drug was studied at 3 dose levels after 5, 30 and 60 minutes of injection. Head-dip count in 5 min was taken as an index of exploration and squares crossed gave the locomotion score. All stimulant drugs significantly suppressed head dipping except caffeine (5 mg/kg) and leptazol (10 mg/kg). Locomotion was also decreased but to a variable degree except with amphetamine (2 and 4 mg/kg) and caffeine (10 and 20 mg/kg) which increased locomotor activity, and picrotoxin causing no significant change. The results reflect an anxiogenic profile of CNS stimulant drugs in animal model of anxiety with probable involvement of central dopaminergic system.


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