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Year : 1995  |  Volume : 27  |  Issue : 3  |  Page : 156-160

Digestive enzymes of rat pancreas and small intestine in response to orally administered mint (Mentha Spicata) leaf and garlic (Allium Sativum) oil

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JNN Sharathchandra

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The influence of mint leaf and garlic oil, the two common ingredients of several digestive stimulant drugs, was examined on digestive enzymes of pancreas and intestinal mucosa and on bile secretion and composition in experimental rats. The test materials were ad-ministered orally at two doses which were either pharmacological dose or 5 times of this. The results indicated that mint leaf had significant stimulatory influence on lipase activity of pancreas and intestinal mucosa, while garlic oil stimulated the enzyme activity only in intestinal mucosa. Mint also stimulated intestinal amylase activity. Garlic oil exhibited a reduction in pancreatic trypsin and chymotrypsin activities. However, these test materials did not have any marked influence on bile secretion and composition.


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