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Year : 1995  |  Volume : 27  |  Issue : 2  |  Page : 130-132

Percutaneous absorption of naproxen from different ointment bases in rats

Correspondence Address:
MSP Sastry

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Source of Support: None, Conflict of Interest: None

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Percutaneous absorption of naproxen from three different ointment bases viz, water washable transparent carbopol gel, water soluble PEG and oleagenous petroleum jelly bases in rats was evaluated indirectly by estimating the % unabsorbed drug at different time intervals after the application of the ointments. Rate of drug absorption (Ka) was faster from gel base (0.36h-1), followed by PEG (0.26h-1) and petroleum jelly (0.12h-1) bases with the corresponding absorption half-lives (t1/2) of 1.93 hrs, 2.67 hrs and 5.78 hrs respectively. The same order of drug absorption was also observed from the three different bases in the in viw plasma concentration time profiles indicating a good correlation between in vivo and % unabsorbed drug studies.


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