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Year : 1995  |  Volume : 27  |  Issue : 2  |  Page : 120-123

The influence of lactational status on the xenobiotic metabolizing enzymes of adult mice

Correspondence Address:
S K Chhabra

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The present study investigates the influence of the lactational state on some hepatic xenobiotic metabolizing enzymes of adult female mouse. Primiparous nursing mothers were sacrificed in the middle of and at the end of the 21 day lactational period i.e. 2 and 3 weeks postpartum respectively and the livers excised. Non-lactating virgin female mice of the same age group were used as the controls and sacrificed along with the experimental groups. Livers from the nursing mothers showed significantly higher activities of glutathione S-transferase (P<0.001) and glutathione reductase (P<0.01) compared to the non-lactating controls. Acid soluble sulfhydryl content (of which 90% is glutathione) and P-450 and bs contents were lower in the maternal liver than in the control (P<0.001). Glutathione peroxidase activity was not affected by the lactational state. The weight of livers of the lactating mice were greater than that of the control mice (P<0.01). The observed differences in some hepatic enzyme activities suggest that differences exist in the rates and extent of hepatic detoxication during this physiological state.


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