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Year : 1995  |  Volume : 27  |  Issue : 2  |  Page : 111-115

Differential effects of diphenylhydantoin and di-N-propylacetate on the protective activity of diazepam against chemically-induced convulsions in mice

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The anticonvulsant activity of diazepam given alone or in combination with diphenylhydantoin (DPH) or di-n propylacetate (DPA) was evaluated in pentylenetetrazol (PTZ) and bicuculline-induced convulsions in male mice. DPH did not influence the seizures induced by either convulsants, but potentiated the anticonvulsant activity of diazepam against PTZ induced convulsions. However, the anticonvulsant activity of diazepam against bicuculline- induced convulsions was not influenced by pretreatment with DPH. On the other hand, pretreatment with DPA caused potentiation of the anticonvulsant activity of diazepam against both PTZ and bicuculline-induced seizures. These data suggest that the enhancement of the anti PTZ activity of diazepam by DPH might be related to an increase in the total number of specific benzodiazepine binding sites, while the anti-bicuculline effect of diazepam does not seem to involve in interaction with benzodiazepine receptor sites. Furthermore, the data also propose that gamma-aminobutyric acid (GABA)-ergic mechanisms may mediate the DPA potentiation of diazepam anticonvulsant activity against PTZ and bicuculline-induced convulsions.


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