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Year : 1995  |  Volume : 27  |  Issue : 1  |  Page : 37-39

Preliminary studies on the anti-inflammatory effects of Swertia chirata in albino rats

Correspondence Address:
Nazrul Islam Chowdhury

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Source of Support: None, Conflict of Interest: None

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Aqueous suspension of total xanthones of Swertia chirata in 5% gum acacia was prepared from the aerial parts of the plant. Its anti-inflammatory effects were investigated in albino rats at a dose level of 50 mg/kg body weight (oral route) against Carrageenin, 5-HT, Dextran, Bradykinin and PGE1 induced hind paw oedema. Schirata exhibited significant antiinflam -matory activity against 5-HT and bradykinin. Mean changes in paw volume revealed the efficacy of the drug against phlogistic agents in the following order: 5-HT>Carrageenin> Bradykinin>Dextran>PGE1. Anti-inflammatory effects of Schirata was found less effective when compared with standard anti-inflammatory drugs like phenylbutazole (50 mg/kg, i.p) and betamethasone (0.5 mg/kg, i.p) in experimental models of acute and subacute inflammation.


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