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Year : 1995  |  Volume : 27  |  Issue : 1  |  Page : 30-33

Disposition kinetics of oxytetracycline in plasma, milk and uterine fluid after i.v. administration in female buffaloes

Correspondence Address:
C Jayachandran

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Source of Support: None, Conflict of Interest: None

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Pharmacokinetics of oxytetracycline (OTC) @5 mg/kg, i.v. in healthy lactating buffaloes was undertaken to determine the level and distribution of oxytetracycline in plasma, milk and uterine fluid. For this, the samples of plasma, milk and uterine fluid were collected at various time intervals (0.08 to 48 h) post i.v. administration. Estimation of the drug concentration was carried out by cylinder plate diffusion method using Bacillus cereus as the test microorganism. The study showed that OTC maintained its minimum effective therapeutic concentration (minimum ETC) of 0.5 (g/ml from 0.08 - > 12 h, 0.5 - > 24 h and 0.5 - 24 h in plasma, milk and uterine fluid, respectively, which suggests that the drug can be effectively used in the treatment of mammary gland and uterine infections apart from its use in other systemic infections. A shorter distribution half-life (tina) of 0.67+ 0.04 h and a comparatively longer elimination half-life (t1/2() of 9.38( 0.17 h obtained in the present study indicate that OTC is distributed at a faster rate but eliminated at a slower rate. The value of tissue plasma concentration during elimination phase [(K12/(K21-())] of 0.98( 0.06 indicates that OTC is expected to be distributed well in different body tissues and fluids and it is supported by the drug concentration obtained in milk and uterine fluid at different time intervals. A high Vdarea of 2.62( 0.06 L/kg also supports the good distribution of OTC.


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