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Year : 1994  |  Volume : 26  |  Issue : 4  |  Page : 301-303

A non-invasive method for screening hepatoprotective drugs against carbon tetrachloride induced hepatotoxicity

Correspondence Address:
D Visweswaram

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Source of Support: None, Conflict of Interest: None

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Carbon tetrachloride (CCl4 ) a pharmacological tool to produce liver damage reduced the urinary excretion of ascorbic acid in rats. Silymarin and extract of Pamarus (shown to be hepatoprotective substances) prevented the CCl4 induced reduction of ascorbic acid excretion in urine. The results indicate that the measurement of ascorbic acid excretion can be used as a non-invasive test for screening protective substances against CCl4 induced hepatotoxicity in rats.


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