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Year : 1994  |  Volume : 26  |  Issue : 3  |  Page : 227-228

Anticonvulsant activity of pyrimidine thiols

Correspondence Address:
A K Gupta

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Source of Support: None, Conflict of Interest: None

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A series of nitrophenyl 4,4,6 trimethyl, 1 H, 4H pyrimidine 2 thiols (NPTP) were synthesised and tested for their anticonvulsant activity in mice against maximal electro shock and metrazol (MET) induced convulsions. Test compounds were given in graded doses (20,40,60,80 mg/Kg i.p.) and compared with phenobarbitone as a standard control. The protection produced by the test compounds was dose dependent. Phenobarbitone, produced 100% protection in the dose of 50 mg/Kg, whereas test compounds exhibited the same effect with 80 mg/Kg except 2 NPTP against MET induced convulsions.


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