| RESEARCH PAPER |
|
| Year : 1994 | Volume
: 26
| Issue : 3 | Page : 218-221 |
The effect of adrenal steroids on imipramine analgesia
SN Mandhane, CT Chopde, AV Muthal
Correspondence Address:
S N Mandhane
 Source of Support: None, Conflict of Interest: None  | Check |
The effect of adrenocorticosteroids on imioramine (IMA) analgesia was evaluated in sham-adrenalectomised (sham-ADX) and adrknalectomised (ADX) rats using tail-flick test. Adrenalectomised rats displayed greater sensitivityto IMA(5-20 mg/kg, i.p.) induced analgesia. Subcutaneous administration of glucocorticoids,. corticosterone -(0.01-10 mg/kg), hydrocortisone (0.5 mg/kg), dexamethasone (0.5 mg/kg), attenuated the analgesic effect of IMA (20 mg/kg) in sham-ADX or ADX rats. Mineralocorticoid, aldosterone (0.5-10 mg/kg), had no effect, Adrenalectomy per se or adrenocorticosteroids per se did not alter the basal tail-flick reaction latency. Thus the enhanced potency of IMA in ADX rats may be mediated by the absence of circulating adrenocorticosteroids.
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