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Year : 1994  |  Volume : 26  |  Issue : 3  |  Page : 179-184

Stealth liposomes-an overview

Correspondence Address:
P Srinath

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Source of Support: None, Conflict of Interest: None

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Many of the applications of liposome drug-delivery systems have been limited by their short circulation half-lives as a result of rapid uptake into the reticuloendothelial (mononuclear-phagocyte) system. Different approaches were taken up to formulate liposomes with prolonged circulation half-lives (Stealth liposomes). A brief review of different methods followed to prepare and characterise stealth liposomes is presented in this article. Bilayer compatible polymers such as polyethyleneglycols, gangliosides and glycolipids are used to prepare these liposomes. Of all gangliosides especially GM1 was found to be most effective.


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