| RESEARCH PAPER
|Year : 1994 | Volume
| Issue : 2 | Page : 153-155
Antidipsogenic action of alpha methyldopa
AK Khare, J Mambwe
Acute peripheral administration of methyldopa (20 mg/kg, i.p.) attenuates drinking response in rats to acute peripheral administration of either isoproternol (25(g/kg bw, s.c.) or hypertonic saline (5 ml/kg bw, i.p.) solution. This antidipsogenic action was not different from that of acute peripheral administration of clonidine (12 (g/kg bw, i.p.). These results suggest that methyldopa has antidipsogenic effect similar to clonidine and support the view that alpha2 adrenoceptors on neuraxis are involved in mediating this effect.
A K Khare
Source of Support: None, Conflict of Interest: None