IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 3157 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 ╗   Next article
 ╗   Previous article
 ╗   Table of Contents

Resource Links
 ╗   Similar in PUBMED
 ╗  Search Pubmed for
 ╗  Search in Google Scholar for
 ╗Related articles
 ╗   Citation Manager
 ╗   Access Statistics
 ╗   Reader Comments
 ╗   Email Alert *
 ╗   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded122    
    Comments [Add]    

Recommend this journal


Year : 1993  |  Volume : 25  |  Issue : 4  |  Page : 199-203

Modification of disposition kinetics of oxytetracycline by paracetamol and endotoxin - induced fever in goats

Correspondence Address:
S Manna

Login to access the Email id

Source of Support: None, Conflict of Interest: None

Rights and PermissionsRights and Permissions

Disposition kinetics of oxytetracycline (20 mg/kg, i.v) in the absence/presence of paracetamol (50 mg/kg, i.v) in both afebrile and endotoxin-induced febrile conditions were studied in female Black Bengal goats. Fever was induced and maintained for 12 h by injecting Escherichia coli endotoxin (0.2 'g/kg, i.v) initially and repeating it at half the dose (0.1 'g/kg) 5h later. The disposition kinetics of oxytetracycline was described by a two compartment open model. The concentrations of oxytetracycline atone (83.60 ˝ 0.80 'g/ml) in afebrile condition at 0.03 hr post- drug administration was higher from the corresponding values of febrile alone (48.30 ˝ 1.60 'g/ml) and combined therapy (72.60 ˝ 4.90 'g/ml; 52.0 ˝ 1.O 'g/ml). Fever alone decreased the concentration of oxytetracycline in blood-The t1/2(() value (5.95 h) was maximum in afebrile paracetamol group followed by febrile alone (4.08 h), febrile paracetamol (3.16 h) and afebrile alone groups (2.78 h) in sequence. The Vd(area) was higher in presence of paracetamol at both afebrile and febrile states as well as febrile alone. The paracetamol did not interfere with the protein binding of oxytetracycline.


Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer | Privacy Notice
Online since 20th July '04
Published by Wolters Kluwer - Medknow