| REVIEW ARTICLE
|Year : 1993 | Volume
| Issue : 4 | Page : 188-192
Medetomidine - A new selective alpha-2 adrenoceptor agonist
BV Venkataraman, MA Nagarani
Medetomidine, an imidazoline derivative is a lipophilic compound with selective (2-adrenoceptor agonist activity. It has a negligible binding affinity for dopaminergic, cholinergic, histaminergic, opiate, adenosine and benzodiazepine receptors. Various in vivo experiments show dose-dependent hypotensive, bradycardia, sedative, anxiolytic, mydriatic, hypothermic and analgesic effects. In general it is more potent than the other an-agonists in central and peripheral actions on (2-adrenoceptors. Effects of medetomidine can be antagonised by prior, simultaneous or subsequent administration of an-antagonists. In human trials it is shown to be well tolerated and the drug may also have therapeutic applications in humans.
B V Venkataraman
Source of Support: None, Conflict of Interest: None