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Year : 1993  |  Volume : 25  |  Issue : 3  |  Page : 170-172

Comparative studies of the effects of calcium channel blockers on glucose Tolerance in normal rats

Correspondence Address:
R N Chattopadhyay

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Source of Support: None, Conflict of Interest: None

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Effect of calcium channel blockers on glucose tolerance in normal rats was studied. Nifedipine, verapamil and diltiazem produced no significant change in blood glucose level in normal rats. But pretreatment with these calcium channel blockers raised the glucose level significantly in rats after glucose load and adrenaline injection. It is concluded that calcium channel blockers have no significant effect on basal insulin release but possibly inhibit its release when body demands an extra release of insulin to maintain homeostasis.


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