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Year : 1993  |  Volume : 25  |  Issue : 3  |  Page : 154-157

Effect of amiodarone on the pharmacokinetics and hypoglycaemic activity of tolbutamide in rabbits

Correspondence Address:
YSR Krishnaiah

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Source of Support: None, Conflict of Interest: None

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Amiodarone was reported to elevate the serum levels of several drugs including digoxin, flecainide, quinidine, phenytoin and warfarin. The effect of amiodarone on the pharmacokinetics and hypoglycaemic activity of tolbutamide was studied initially in a rabbit model to find out the possible drug interaction such that the clinical relevance can be studied if necessary at a later stage. Amiodarone (100 mg/kg, oral once daily for one week) significantly increased the absorption rate constant, terminal half-life and AUC0-( of tolbutamide (40 mg/kg, oral) in normal rabbits. The hypoglycaemic activity of tolbutamide was also enhanced and prolonged sig-nificantly in amiodarone treated rabbits. It appears that amiodarone increased the absorption and decreased the hepatic metabolism of tolbutamide in rabbits. Further studies are needed to find out the clinical relevance of this tolbutamide-amiodarone interaction observed in rabbits.


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