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Year : 1993  |  Volume : 25  |  Issue : 3  |  Page : 149-153

3-Cyano-4-methyl-5vinyl pyridine: a potent synthetic hepatoprotective agent

Correspondence Address:
PKS Visen

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Source of Support: None, Conflict of Interest: None

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Compound 3-cyano-4-methyl-5-vinyl pyridine (compound 89/62) produced a dose dependent (3-12 mg/kg, p.o.) choleretic activity in rats and significant anticholestatic activity (38-l00%) against paracetamol induced cholestasis. It also increased the viability of hepatocytes as assessed by trypan blue exclusion and oxygen uptake tests, Paracetamol induced biochemical changes in serum and isolated hepatocytes were normalised by the pretreatment with this compound.


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