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Year : 1993  |  Volume : 25  |  Issue : 3  |  Page : 146-148

Drug interaction of tolbutamide with ketoconazole in diabetic rabbits

Correspondence Address:
YSR Krishnaiah

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Source of Support: None, Conflict of Interest: None

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A study was carried out to find out the therapeutic implications of the tolbutamide - ketoconazole interaction in diabetic rabbits. Ketoconazole treatment (20 mgkg, oral once daily for one week) significantly increased and prolonged the antidiabetic effect of tolbutamide (40 mg/kg, oral) in diabetic rabbits. The AUC0-( and the terminal half-life of tolbutamide were increased significantly by ketoconazole indicating the decrease in its hepatic metabolism.


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