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Year : 1993  |  Volume : 25  |  Issue : 3  |  Page : 136-139

Studies on the mechanism of the hypothermic response to IDPH-791

Correspondence Address:
A Y Junnarkar

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Source of Support: None, Conflict of Interest: None

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IDPH-791, a new central muscle relaxant, produced dose dependent hypothermia in mice. The possible mechanism involved in this response was investigated. Adrenergic blocking agents (prazosin, phenoxybenzamine, yohimbine and propranolol), dopaminergic antagonist (haloperidol), serotonergic antagonist (methysergide) and antihistamines (mepyramine and cimetidine) did not cause any significant modification of the hypothermia. Similarly prostaglandin synthesis inhibitors (ketoprofen, indomethacin and paracetamol) also did not alter the hypothermia induced by IDPH-791, thus ruling out the possibility of central prostaglandin involvement. Atropine reversed the hypothermic response and physostigmine potentiated it, suggesting the possible involvement of acetylcholine acting through muscarinic receptors. There was also significant increase in total acetylcholine content of rat brain on pretreatment with IDPH 791. It is concluded that central muscarinic receptor may be involved in the hypothermic response of IDPH-791.


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